Interleukin 1-α: A Modulator of Melanocyte Homeostasis in Vitiligo
نویسندگان
چکیده
Background: Vitiligo is a hypomelanotic autoimmune skin disorder arising from a breakdown in immunological self-tolerance, which leads to aberrant immune responses against melanocytes leading to selective destruction of melanocytes. High levels of Interleukin 1(IL1) have been reported in various autoimmune disorders including vitiligo. The aim of present study was to explore the effect of IL1-α on melanocyte biology by monitoring the melanocyte viability, IL1R1 membrane expression, melanogenesis (TYR, TYRP1 and MITF-M) and other immuno modulatory molecules (IL1A, IL1B, IL1RN,IL1R1 IL8, TNFA, IL6, and ICAM1) upon exogenous stimulation of IL1α on primary cultured normal human melanocytes (NHM).
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